CRS 2017 - quick release/slow-release fixed-dose combination (FDC) dose - weight is proportional to the formula

This study aims to evaluate two kinds of release (IR) dose with a constant speed and variable sustained release (SR) interpretation of the dose and dose or variable speed constant sustained release (SR) dose of model drugs (water-soluble) FDC dose - weight is proportional to the formula;While maintaining a similar drug release curve and double FDC tablet diameter change to provide the most ideal tablet thickness effects.