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Solubilization polymer AFFINISOL ™ series
Solve difficult soluble problems
Hot-melt extrusion (HME) dedicated AFFINISOL ™ hydroxypropyl methyl cellulose
Drug solubility difference of active ingredient (API) is a major challenge facing the pharmaceutical industry.AFFINISOL ™ polymer for solubilization needs to solve these drugs active ingredient and customized.
AFFINISOL ™ HPMC HME polymer
AFFINISOL ™ HPMC HME (hot melt extrusion type hydroxypropyl methyl cellulose) designed for hot melt extrusion formula design, pharmaceutical companies through the use of this polymer, to improve the solubility and suppress API API recrystallization.
As a kind of cellulose polymers, AFFINISOL ™ HPMC HME not only have the hydroxypropyl methylcellulose common crystallization inhibition performance, and without use of plasticizer in a wider temperature range hot melt extrusion.At the same time, AFFINISOL ™ HPMC HME can simplify formula requirements, improve the physical stability, and provides various functions in drug release curve.
The application of AFFINISOL ™ series polymer
AFFINISOL ™ series polymer is dedicated to solve the problem of solubilization of API performance requirements and customized.
HME as formula technology applied to the pharmaceutical industry is rapidly developing, using the two technologies will increase the biopharmaceutics classification system in class II and class IV of the solubility of difficult soluble drugs, and prevent nucleation.
AFFINISOL ™ is a registered trademark IFF company.© 2021 IFF. All rights reserved
Product literature
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AAPS 2017 - by assessing thermal degradation determination of acetic acid hydroxypropyl methyl cellulose succinate hot melt extrusion and grinding process window
Download the documentAAPS 2018 - based evaluation of amorphous solid dispersions method for determination of the degree of release
Download the documentThis study aims to build a used to evaluate different itraconazole of amorphous solid dispersions (ASD) formula is to distinguish the force release method.At the same time, to the release of all sorts of different conditions, such as medium, volume and fluid dynamics were also studied.
AAPS 2019 - crushing technology on preparation of amorphous solid dispersions of hot melt extrusion effect (English version)
Download the documentAAPS 2019, Texas
AAPS relying on yesterday of the preparation of 2019 - spray drying cloth based evaluation and characterization of solid dispersions (English version)
Download the documentAAPS 2019, Texas
AAPS 2021 - additive effect on the properties of amorphous solid dispersions
Download the documentAAPS_2018_ amorphous solid dispersions in the performance assessment of the risks of crystallization
Download the documentAmorphous drug recrystallization is amorphous solid dispersions (ASD) one of the biggest risk to the physical instability;This may be on the solubility, release and bioavailability.This study aims to use the experimental design of ASD samples to assess the degree of crystallization of amorphous solid dispersions release effect.
CRS 2018 - about the use of hot melt extrusion the basic assessment of itraconazole solid dispersion preparation and characterization
Download the documentThrough grade change according to the drug and HPMCAS formula, can achieve release curve and solubility increase the variety of products such as performance, at the same time, under the condition of accelerated stability 1 months can still keep drug to amorphous form.
CRS 2019 - containing acetic acid hydroxypropyl methyl cellulose succinate (HPMCAS) based on exam yesterday (Etoricoxib) spray drying amorphous solid dispersions of process optimization research
Download the documentThe aim of this study was to evaluate the relying on the test yesterday (ETO) and preparation of solid dispersions HPMCAS key technology conditions of spray drying, solid content, the influence of nozzle diameter and nozzle airflow.
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