To understand the cause of the high brittle broken degree and its prevention
Imagine the perfect piece of core: no depletion edge, off powder or lobes, group after group of continuous production.In the card nu-lax, we have experts can be forward-looking planning and insight to help realize this vision.Like any piece of core prescription, the characteristics of active pharmaceutical excipients (including the choice of film coating) and the choice of batch production process and so on also can affect tablet core is prone to low brittle broken or high brittle broken degrees.Let's take a look at how can ease the brittle broken problem, improve your product batch.
First of all, let's take a look at its core content: core
Therefore, solving the core hardness and disintegrating performance between the balance problem is very important.We have seen a lot of "extreme formula" case, suppress tablet core is very hard, so you need to add the disintegrating agent.However, the high proportion of super disintegrating agent can lead to stronger moisture and higher raw material costs.
With card nu-lax rich experience, we suggest to take a more robust approach: has the certain pressure for a little piece of core hardness can, don't be too hard, can rapidly disintegrating tablet core at the same time, so if you need to add the disintegrating agent, and also not many.
Good core hardness depends on choosing the appropriate materials, and microcrystalline cellulose (MCC) and the good part of ™ the collocation of gel corn starch is used, to create the core hardness and disintegration of the balance.
Of course, regular inspection and maintenance of tablet punch and die is a good practice.Because wear preforming punch to not an adverse effect on the rim of the core of wear-resisting, caused the ke edge.
At the same time, the slice of core shape and plate shape design also can affect the strength of the tablet core and brittle broken degrees.In the coating process, compared to the edge of flat/edge is very sharp, narrow shape core, circular piece can be more evenly, or the small power of wear and tear.
Second: coating
Thin film coating, besides make tablet can "attractive" can strengthen and protect the tablet core.If your core brittle broken from the start, you need to do some special protection.It is no exaggeration to say that your choice of film coating, can make the finished product, can also damage to the finished product, so please choose wisely.
The progress of the use of polymer film coating technology, such as the use of poly (vinyl alcohol) (PVA)/PVA/PEG copolymer polymers, such as, can improve the adhesion of the coating film on the surface of tablet core sex - even those who contain wax components of core.This film coating technology has high productivity and coating process is significantly faster than traditional HPMC coating system, compared with before, in the case of can also produce perfect products, your tablet core of time exposed to harsh coating environment can become less.
So, please contact us as soon as possible, get the process to help you to choose the appropriate coating for the product.
Finally, let's check: process
Only when enlarge the challenge for the coating, it is not surprising that;In the process of r&d performance perfect coating, can be a problem in the production of amplification.
When a piece of core is put into a mass production of the coating pan, the deeper the bed means that the more pieces of core pressure on each other, please remember this is very important, because it will even sometimes destructive to slice of core put greater pressure.
Some people may think that the "simple" is to reduce the coating pot place less capacity - that is the core.Many coating pan, however, must be the best filling quantity range, if the tablet core filling quantity is not enough, tablet core will not be able to roll and mix well.This will bring a series of new problems, different including process efficiency is lower, coating uniformity is poorer, or coat film cracking, glue, etc.
If other aspects are not too late to change (or other ways), you can also make some adjustment process.When coating brittle break of poor degree of core, should be as soon as possible in the form the original core surface protection layer.This means that in the first third of the whole process of coating spray as soon as possible, so that it can rapidly form some coating layer;Then speed can slow down to "normal" speed, to ensure that the required coating uniformity can be obtained.
In card nu-lax, our goal is to help customers at any time a perfect tablet is prepared.If we had contact with you earlier, you can first to understand your current tablet core prescription, coating, the challenge for the production process, can better improve the slice of core brittle broken degrees, ensure the quality of products.
